MRPS5 Knowpia

MRPS5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J9M
Identifiers
Aliases	MRPS5, MRP-S5, S5mt, mitochondrial ribosomal protein S5, 28S ribosomal protein S5, mitochondrial
External IDs	OMIM: 611972; MGI: 1924971; HomoloGene: 32726; GeneCards: MRPS5; OMA:MRPS5 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	95,122,027 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	127,448,749 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; pancreatic epithelial cell; ; tibialis anterior muscle; ; right lobe of liver; ; gastrocnemius muscle; ; renal medulla; ; deltoid muscle; ; Brodmann area 9; ; hypothalamus; ; right adrenal gland;
	Top expressed in
	ventricular zone; ; embryo; ; muscle of thigh; ; spermatocyte; ; embryo; ; blastocyst; ; right kidney; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; epiblast;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of ribosome; RNA binding;
Cellular component	mitochondrial inner membrane; ribosome; mitochondrion; cytosolic small ribosomal subunit; mitochondrial small ribosomal subunit;
Biological process	mitochondrial translational elongation; mitochondrial translational termination; protein biosynthesis;
	Sources:Amigo / QuickGO
Orthologs
	64969
	77721
	ENSG00000289685
	ENSMUSG00000027374
	P82675
	Q99N87
	NM_031902; NM_001321995; NM_001321996; NM_001321997
	NM_029963
	NP_001308924; NP_001308925; NP_001308926; NP_114108
	NP_084239
	Wikidata
View/Edit Human	View/Edit Mouse

28S ribosomal protein S5, mitochondrial, otherwise called uS5m, is a protein that in humans is encoded by the MRPS5 gene.^[5]

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000289685 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027374 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: MRPS5 mitochondrial ribosomal protein S5".