This list is arranged by drainage basin, from north to south, with respective tributaries indented under each larger stream's name. All rivers in South Carolina drain to the Atlantic Ocean.

• Little River
• Pee Dee River
  • Old Dead River
  • Sampit River
  • Black River
    • Black Mingo Creek
    • Pocotaligo River
  • Little Pee Dee River
    • Lumber River
  • Lynches River
    • Little River
  • Jeffries Creek
  • Black Creek

• Santee River (North Santee River and South Santee River are distributaries)
  • Little River
  • Wateree River
    • Catawba River
      • Fishing Creek
  • Congaree River
    • Dead River
    • Old Dead River
    • Broad River
      • Little River
      • Enoree River
      • Tyger River
        • Fairforest Creek
        • North Tyger River
          • Middle Tyger River
        • South Tyger River
      • Sandy River
        • Little Sandy River
      • Pacolet River
        • Lawsons Fork Creek
        • North Pacolet River
        • South Pacolet River
    • Saluda River
      • Little Saluda River
      • Bush River
      • Little River
      • Reedy River
      • North Saluda River
      • Middle Saluda River
      • South Saluda River
        • Oolenoy River
    • Gills Creek

• Wando River
• Cooper River
  • Back River
• Ashley River
• Stono River
• Kiawah River

• Edisto River (North Edisto River and South Edisto River are distributaries)
  • Four Holes Swamp
  • North Fork Edisto River
    • Bull Swamp Creek
  • South Fork Edisto River
    • Little River
• Ashepoo River
• Combahee River
  • Little Salkehatchie River
  • Salkehatchie River
• Coosaw River
• Morgan River (SC)
• Story River
• Beaufort River
• Broad River
  • Colleton River
  • Pocotaligo River
  • Coosawhatchie River
    • Tulifiny River
• May River
• New River
• Wright River

• Savannah River
  • Stevens Creek
  • Little River
  • Rocky River
  • Seneca River
    • Keowee River
      • Little River
        • Flat Shoals River
      • Toxaway River
        • Horsepasture River
      • Whitewater River
        • Thompson River
  • Tugaloo River
    • Chauga River
    • Chattooga River
      • East Fork Chattooga River

• Ashepoo River
• Ashley River
• Back River
• Bates Old River
• Beaufort River
• Black River
• Black Mingo Creek
• Broad River (northern)
• Broad River (southern)
• Bull Swamp Creek
• Bush River
• Catawba River
• Chattooga River
• Chauga River
• Chechessee River
• Combahee River
• Colleton River
• Congaree River
• Cooper River (incl. East & West Branches, and Back River)
• Coosaw River
• Coosawhatchie River
• Dead River
• East Fork Chatooga River
• Edisto River (incl. North & South Forks)
• Enoree River
• Flat Shoals River
• Four Holes Swamp
• Gills Creek
• Great Pee Dee River
• Grove Creek
• Harbor River
• Horsepasture River
• Keowee River
• Little Lynches River
• Little Pee Dee River
• Little River (Broad River tributary)
• Little River (Edisto River tributary)
• Little River (Horry County, South Carolina)
• Little River (Lynches River tributary)
• Little River (McCormick County, South Carolina)
• Little River (Oconee County, South Carolina)
• Little River (Saluda River tributary)
• Little River (Santee River tributary)
• Little Salkehatchie River
• Little Saluda River
• Little Sandy River
• Lumber River
• Lynches River
• May River
• Morgan River (SC)
• New River
• Oolenoy River
• Okatee River
• Old Dead River (Marlboro County)
• Old Dead River (Richland County, Congaree National Park)
• Pacolet River (incl. North, South, and Lawson's Fork Creek)
• Pocotaligo River (Black River tributary)
• Pocotaligo River (Broad River tributary)
• Reedy River
• Rocky River
• Salkehatchie River
• Saluda River (incl. North, Middle, and South Forks)
• Sampit River
• Sandy River
• Santee River (incl. North & South)
• Savannah River
• Seneca River
• Stevens Creek
• Stono River
• Story River
• Thompson River
• Toxaway River
• Tugaloo River
• Tyger River (incl. North, Middle, and South)
• Waccamaw River
• Wando River
• Wateree River
• Whitewater River
• Wright River

• List of rivers in the United States
• List of lakes in South Carolina

• USGS Geographic Names Information Service
• USGS Hydrologic Unit Map - State of South Carolina (1974)