Marie of Lusignan or Marie I de Lusignan (died in Poitou, 1 October 1260; buried at the Abbey of Foucarmont), was the only child of Raoul II of Lusignan and his second wife, Yolande de Dreux.^[1] She became Dame d'Exoudun, Countess of Eu on the death of her father in 1246.

She was married around 1249 to Alphonso of Brienne^[1] who became Count of Eu by this marriage.

Marie and Alphonso had at least two children:

• John I of Brienne, Count of Eu^[2]
• Blanche, Abbess of Maubuisson