The Mazepa family (Ukrainian: Мазепа) was a noble Ruthenian/Ukrainian family. Their origin can be traced back to 1544, when the Ukrainian szlachtych Mykola Mazepa-Koledynski was given a khutor (farmstead) Kamyanets (which later grew to become the village of Mazepyntsi) by King Sigismund I for his duty.

Mazepa
Mazepa
Current region	Ukraine
Place of origin	Mazepyntsi (Ukrainian article)
Members	Ivan Mazepa Fedir Mazepa

Mykola Mazepa-Koledynski had two grandsons:

• Fedir Mykhaylovych Mazepa – a Cossack otaman. He fought against the Poles together with Hryhory Loboda, Severyn Nalyvaiko & Krzysztof Kosiński. Later he was caught and together with Severyn Nalyvaiko was executed in Warsaw.
• Stepan-Adam Mazepa. His spouse Maryna Mazepa (died 1707) of Mokiev descent became a nun and later hegumenia of the Frolov-Voznesenski Monastery [uk] in Kiev. They had a son, Ivan, and a daughter, who later married Andrew Voynorovskiy.