Seiler is a surname. Notable people with the surname include:

• Alexander Seiler I (1819–1891), Swiss Hotel Pioneer
• Hermann Seiler (1876–1961) Swiss Hotel Pioneer & Politician
• Jack Seiler (born 1963), American politician and Mayor of Fort Lauderdale, Florida
• Kerim Seiler (born 1974), Swiss artist and architect
• Lewis Seiler (1890–1964), American film director
• Paul Seiler (1945–2001), American football player
• Reinhard Seiler (1909–1989), German Luftwaffe pilot
• Robert Eldridge Seiler (1912–1998), American judge on the Missouri Supreme Court
• Sebastian Seiler (1810–1890), German journalist
• Sonny Seiler (1933–2023), American attorney and bulldog owner