1-acylglycerol-3-phosphate O-acyltransferase

Summary

In enzymology, a 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) is an enzyme that catalyzes the chemical reaction

1-acylglycerol-3-phosphate O-acyltransferase
Identifiers
EC no.2.3.1.51
CAS no.51901-16-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate CoA + 1,2-diacyl-sn-glycerol 3-phosphate

Thus, the two substrates of this enzyme are acyl-CoA and 1-acyl-sn-glycerol 3-phosphate, whereas its two products are CoA and 1,2-diacyl-sn-glycerol 3-phosphate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase. Other names in common use include 1-acyl-sn-glycero-3-phosphate acyltransferase, 1-acyl-sn-glycerol 3-phosphate acyltransferase, 1-acylglycero-3-phosphate acyltransferase, 1-acylglycerolphosphate acyltransferase, 1-acylglycerophosphate acyltransferase, and lysophosphatidic acid-acyltransferase. This enzyme participates in 3 metabolic pathways: glycerolipid metabolism, glycerophospholipid metabolism, and ether lipid metabolism.

References edit

  • Frentzen M, Heinz E, McKeon TA, Stumpf PK (1983). "Specificities and selectivities of glycerol-3-phosphate acyltransferase and monoacylglycerol-3-phosphate acyltransferase from pea and spinach chloroplasts". Eur. J. Biochem. 129 (3): 629–636. doi:10.1111/j.1432-1033.1983.tb07096.x. PMID 6825679.
  • Hill EE, Lands WE (1968). "Incorporation of long-chain and polyunsaturated acids into phosphatidate and phosphatidylcholine" (PDF). Biochim. Biophys. Acta. 152 (3): 645–8. doi:10.1016/0005-2760(68)90109-4. hdl:2027.42/33183. PMID 5661029.
  • Yamashita S, Hosaka K, Numa S (1973). "Acyl-donor specificities of partially purified 1-acylglycerophosphate acyltransferase, 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes". Eur. J. Biochem. 38 (1): 25–31. doi:10.1111/j.1432-1033.1973.tb03028.x. PMID 4774123.