143 may refer to:

• 143 (number), a natural number
• AD 143, a year of the 2nd century AD
• 143 BC, a year of the 2nd century BC
• 143 (EP), a 2013 EP by Tiffany Evans
• 143 (album), a 2015 album by Bars and Melody
• 143 (2004 film), an Indian Telugu film
• 143 (2022 film), an Indian Marathi film
• "1-4-3 (I Love You)", a 2013 song by Henry Lau from the EP Trap
• 143 (West Midlands) Brigade
• 143 Records, record label of producer David Foster
• KiYa 143, a locomotive type
• 143 Adria, a main-belt asteroid