• Considered the start of the Mannerism art period
• The oldest known painting depicting Stockholm is painted in the church of Storkyrkan.

Painting edit

• Albrecht Altdorfer – Departure of Saint Florian
• Domenico Campagnola – Gerolamo
• Gerard David – The Virgin and Child in a landscape (approximate date)
• Gerard David or circle of Jan Mabuse – Our Lady of the Fly (approximate date)
• Il Garofalo – Ascension of Christ
• Quentin Matsys – Portrait of a woman
• Francesco Melzi – Flora
• Raphael – Transfiguration
• Titian – Venus Anadyomene (approximate date)
• Lucas van Leyden – Lot and his Daughters (approximate date)
• Jan van Scorel – Sippenaltar
• Pseudo Jan Wellens de Cock – Calvary (approximate date)
• Portrait of Francis I of France (completed by this date)

• February 23 (baptised) - Ercole Procaccini the Elder, Italian painter mainly active in Milan (died 1595)
• June 29 - Nicolás Factor, Spanish painter of the Renaissance period (died 1583)
• date unknown
  • Gaspar Becerra, Spanish painter and sculptor (died 1570)
  • Leonardo Brescia, Italian painter (died 1582)
  • Mirabello Cavalori, Italian painter mainly active in Florence (died 1572)
  • Claudio de Arciniega, Spanish sculptor and architect (died 1593)
  • Giacomo del Duca, Italian sculptor (died 1601)
  • Étienne Dupérac, French painter, draughtsman and engraver, topographer and antiquarian (died 1607)
  • Giorgio Ghisi, Italian engraver from Mantua (died 1582)
  • David Kandel, Strasbourg-born botanical illustrator (died 1592)
  • Domenico Poggini, Italian sculptor (died 1590)
  • Giuseppe Porta, Italian painter active mainly in Venice (died 1575)
  • Martin Van Cleve, Flemish painter of the Van Cleve family (died 1570)
• probable
  • Hans Eworth, Flemish painter (died 1574)
  • Marcus Gheeraerts the Elder, Flemish printmaker and painter associated with the English court of the mid-16th Century (died 1590)
  • Francesco Imparato, Italian painter active mainly in his natal city of Naples (died 1570)
  • Girolamo Porro, Italian engraver on wood and on copper (died unknown)
  • Martino Rota, Croatian artist and printmaker (died 1583)
  • Hugues Sambin, French sculptor and woodworker (died 1601)
  • (born 1520/1524): Giovanni Battista Moroni, Italian painter of the mannerist period (died 1579)

• April 6 - Raphael, Italian painter and architect of the High Renaissance (born 1483)^[1]
• April 11 - Agostino Chigi, Italian banker and patron of the arts (born 1466)
• December 6 - Bartolomé Ordóñez, Spanish sculptor (born 1480)
• date unknown
  • Raffaello Botticini - Italian Renaissance painter (born 1474)
  • Sheikh Hamdullah, Ottoman master of Islamic calligraphy (born 1436)
  • Sultan Ali Mashhadi, Persian calligrapher and poet (born 1453)
  • Marx Reichlich, Austrian painter of primarily religious scenes (born 1460)
  • Niccolo Rondinelli, Italian painter active mainly in Ravenna (born 1468)