February 3 – The National Deaf Mute College (later renamed Gallaudet University) is established in Washington, D.C., becoming the first school for the advanced education of the deaf.
May 1 – Stephen Adams, U.S. Senator from Mississippi from 1852 to 1857 (born 1807)
May 26 – James Bell, U.S. Senator from New Hampshire from 1855 to 1857 (born 1804)
June 19 – Alexander Twilight, educator and minister, first African-American known to have earned a bachelor's degree from an American college or university (Middlebury College, 1823) (born 1795)