The 1962 Senate race took place alongside a gubernatorial race that garnered most of the media's attention. Van Zandt criticized Clark for being an idealistic liberal and stressed an anti-communist platform. He also attacked Clark for Clark's support of the Kennedy administration's foreign policy towards both China and Cuba. In return, Clark portrayed Van Zandt as a proponent of McCarthyism who would be "trigger happy" as a Senator.
In the end, Clark was re-elected to the United States Senate, winning his second term. He beat Van Zandt in the nine-county area of Southwestern Pennsylvania surrounding Pittsburgh by nearly 200,000 votes, but lost Central Pennsylvania and the Philadelphia suburbs to Van Zandt. Clark increased his margin of victory in the Southwest from 1956, and his 108,000 vote margin in Allegheny County was an important factor in his victory.