The elections were announced on Radio Malawi on 17 November 1963.^[2] The constituency borders were finalised on 11 March. Candidates were nominated on 6 April.^[2]

There were two voter rolls; the initial plan was for Africans and mixed-race people identifying as African to be on a general roll and for non-Africans and mixed-race people not identifying as African to be on a special roll.^[2] All people over the age of 21 who had been in Nyasaland for at least two years were given the vote, except Africans who were not from Nyasland or one of the neighbouring countries (Northern Rhodesia, Portuguese East Africa or Tanganyika).^[2] The general roll was to elect 50 members and the special roll five.^[2] The special roll created some controversy; the Nyasaland Constitutional Party opposed the inclusion of Asians on the special roll, as they would outnumber the Europeans.^[2] In late December the debate shifted to whether the special roll seats should exist at all. Ultimately the decision was made to have a general roll for Africans, Asians and mixed-race people, and a special roll for Europeans.^[2]

However, as no census had been taken since 1946, there were no reliable estimates of population and the figure had to be extrapolated from the number of taxpayers, with the number of taxpayers (which was limited to men over the age of 25) was doubled and another 25% added to account for tax evaders; the total figure arrived at was roughly 1.5 million.^[2] Voter registration took place between 30 December and 19 January 1963, in which 1,871,170 people registered for the general roll and 814 for the special roll. With so few people registering for the special role, Minister for Transport and Communications Colin Cameron campaigned for the abolition of the special roll, writing to every European resident in the country. The final decision of the Secretary of State was to reduce the number of special roll seats to three.^[2] Another brief period of registration was allowed between 24 and 29 February for Europeans who had missed out on registering for the special roll. However, the 620 people that registered in this period were added to the general roll.^[2] This gave a total of 1,871,790 people registered on the general roll.^[2]

During a mass meeting on an airfield between Cholo and Mlanje on 15 March, Banda announced that he had chosen 50 candidates to represent the party in the elections, of which 49 were men and one a woman, and that the party would not contest the special roll seats.^[2] The Nyasaland Constitutional Party candidates were announced a few days later.^[2] Following Banda's announcement, the MCP worked to ensure it would face no opposition in the elections, and in late March, the only party opposed to the MCP, Mbadwa, announced that it would not run.^[2]