2,5-Dimethoxy-4-trifluoromethylamphetamine

Summary

2,5-Dimethoxy-4-trifluoromethylamphetamine (DOTFM) is a psychedelic drug of the phenethylamine and amphetamine chemical classes. It was first synthesized in 1994 by a team at Purdue University led by David E. Nichols.[1] DOTFM is the alpha-methylated analogue of 2C-TFM, and is around twice as potent in animal studies. It acts as an agonist at the 5-HT2A and 5-HT2C receptors.[1] In drug-substitution experiments in rats, DOTFM fully substituted for LSD and was slightly more potent than DOI.[1]

2,5-Dimethoxy-4-trifluoromethylamphetamine
Clinical data
Other names2,5-Dimethoxy-4-trifluoromethylamphetamine
Legal status
Legal status
Identifiers
  • (RS)-1-[2,5-Dimethoxy-4-(trifluoromethyl)phenyl]propan-2-amine
CAS Number
  • 159277-07-3 ☒N
    159277-12-0 (hydrochloride)
PubChem CID
  • 10400521
ChemSpider
  • 8575959 checkY
ChEMBL
  • ChEMBL6620 checkY
CompTox Dashboard (EPA)
  • DTXSID40439330 Edit this at Wikidata
Chemical and physical data
FormulaC12H16F3NO2
Molar mass263.260 g·mol−1
3D model (JSmol)
  • Interactive image
  • FC(F)(F)c1cc(OC)c(cc1OC)CC(N)C
  • InChI=1S/C12H16F3NO2/c1-7(16)4-8-5-11(18-3)9(12(13,14)15)6-10(8)17-2/h5-7H,4,16H2,1-3H3 checkY
  • Key:WPGOTSORDNBMHP-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

See also edit

References edit

  1. ^ a b c Nichols DE, Frescas S, Marona-Lewicka D, Huang X, Roth BL, Gudelsky GA, Nash JF (1994). "1-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane: a potent serotonin 5-HT2A/2C agonist". Journal of Medicinal Chemistry. 37 (25): 4346–4351. doi:10.1021/jm00051a011. PMID 7996545.