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2-hydroxyphytanoyl-CoA lyase 
Summary
2-Hydroxyphytanoyl-CoA lyase is a peroxisomal enzyme involved in the catabolism of phytanoic acid by α-oxidation. It requires thiamine diphosphate (ThDP) as cofactor.[1]
| 2-hydroxyacyl-CoA lyase 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | HACL1 | ||||||
| Alt. symbols | HPCL | ||||||
| NCBI gene | 26061 | ||||||
| HGNC | 17856 | ||||||
| OMIM | 604300 | ||||||
| RefSeq | NM_012260 | ||||||
| UniProt | Q9UJ83 | ||||||
| Other data | |||||||
| Locus | Chr. 3 p24.3 | ||||||
| |||||||
It is classified under EC number 4.1.
References edit
- ^ Foulon V, Antonenkov V, Croes K, et al. (1999). "Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids". Proc. Natl. Acad. Sci. U.S.A. 96 (18): 10039–44. Bibcode:1999PNAS...9610039F. doi:10.1073/pnas.96.18.10039. PMC 17838. PMID 10468558.
External links edit
Media related to 2-hydroxyphytanoyl-CoA lyase at Wikimedia Commons- 2-hydroxyphytanoyl-coenzyme+A+lyase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
