2C-T-4

Summary

2C-T-4 (2,5-dimethoxy-4-isopropylthiophenethylamine) is a psychedelic phenethylamine of the 2C family. It was first synthesized by Alexander Shulgin and is used as entheogenic recreational drug.

2C-T-4
Names
Preferred IUPAC name
2-{2,5-Dimethoxy-4-[(propan-2-yl)sulfanyl]phenyl}ethan-1-amine
Identifiers
  • 207740-25-8 checkY[chemspider]
3D model (JSmol)
  • Interactive image
ChEMBL
  • ChEMBL338259 checkY
ChemSpider
  • 21106232 checkY
KEGG
  • C22735 checkY
  • 44350070
UNII
  • 558WSD71D4 ☒N
  • DTXSID60893915 Edit this at Wikidata
  • InChI=1S/C13H21NO2S/c1-9(2)17-13-8-11(15-3)10(5-6-14)7-12(13)16-4/h7-9H,5-6,14H2,1-4H3 checkY
    Key: HDYZSVKZKDPLDT-UHFFFAOYSA-N checkY
  • InChI=1/C13H21NO2S/c1-9(2)17-13-8-11(15-3)10(5-6-14)7-12(13)16-4/h7-9H,5-6,14H2,1-4H3
    Key: HDYZSVKZKDPLDT-UHFFFAOYAR
  • CC(C)Sc1cc(OC)c(cc1OC)CCN
Properties
C13H21NO2S
Molar mass 255.38 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Chemistry edit

2C-T-4 is the 2-carbon homolog of aleph-4. The full chemical name is 2-[4-(isopropylthio)-2,5-dimethoxyphenyl]-ethanamine. The drug has structural and pharmacodynamic properties similar to 2C-T-7 and 2C-T-19.[citation needed]

Effects edit

2C-T-4 produces psychedelic and entheogenic effects that develop slowly and can last 8–16 hours.[medical citation needed] While users may experience virtually no effects for the first hour after ingestion, results vary drastically between individuals and range from hallucination and euphoria to intense sickness and anxiety.[1] Shulgin devoted a chapter in the first part of his book PiHKAL to this compound, describing an intense "plus-four" psychedelic experience mediated by a twelve milligram dose.

Pharmacology edit

The mechanism that produces 2C-T-4's hallucinogenic and entheogenic effects has not been specifically established, however it is most likely to result from action as a 5-HT2A serotonin receptor agonist in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines for which the mechanism of action is known.

Popularity edit

2C-T-4 is relatively unknown on the black market, but has been sold to a limited extent on the research chemical market.

Drug prohibition laws edit

Canada edit

As of October 31, 2016, 2C-T-4 is a controlled substance (Schedule III) in Canada.[2]

China edit

As of October 2015 2C-T-4 is a controlled substance in China.[3]

Denmark edit

2C-T-4 is added to the list of Schedule B controlled substances.[4]

Sweden edit

Sveriges riksdags health ministry Statens folkhälsoinstitut classified 2C-T-4 as "health hazard" under the act Lagen om förbud mot vissa hälsofarliga varor (translated Act on the Prohibition of Certain Goods Dangerous to Health) as of Jul 15, 2007, in their regulation SFS 2007:600 listed as 2,5-dimetoxi-4-isopropyltiofenetylamin (2C-T-4), making it illegal to sell or possess.[5]

United States edit

As of July 9, 2012, 2C-T-4 is a Schedule I substance in the United States, under the Synthetic Drug Abuse Prevention Act of 2012.[6]

Homologue edit

 
Ψ-2C-T-4, the homologue of 2C-T-4

2C-T-4 has one homologue, the structural isomer Ψ-2C-T-4 (2,6-dimethoxy-4-(i)-propylthiophenethylamine). This compound was tested by Alexander Shulgin at a dose of 12 mg.

At this dosage its duration was very short and it produced few effects, however based on the research into the better characterized compound Ψ-DOM, the potency of Ψ-2C-T-4 is likely to be around 1/3 that of 2C-T-4 itself, so a more effective dosage of Ψ-2C-T-4 might be in the region of 20–60 mg;[1] however high doses such as this might well be associated with toxic side effects, and so extreme caution would be advised.

References edit

  1. ^ a b Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628.
  2. ^ "Canada Gazette – Regulations Amending the Food and Drug Regulations (Part J — 2C-phenethylamines)". 4 May 2016.
  3. ^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Archived from the original on 1 October 2015. Retrieved 1 October 2015.
  4. ^ "Retsinformation".
  5. ^ Larsson, Maria. "Svensk författningssamling" (PDF). Retrieved January 24, 2022.
  6. ^ Portman. "Synthetic Drug Abuse Prevention Act of 2012". Govtrack. Retrieved 22 July 2012.

External links edit

  • PiHKAL #41 2C-T-4
  • 2C-T-4 Entry in PiHKAL • info
  • Ψ-2C-T-4 Entry in PiHKAL • info