3C-DFE is a lesser-known psychedelic drug, which is a fluorinated derivative of 3C-E. It was first synthesised by Daniel Trachsel in 2002,[1][2] and has been reported as showing similar psychedelic activity to related compounds, with a dose range of around 20–40 mg and a duration of approximately 10 hours.[3]: 736 Despite its reported psychedelic activity, binding studies in vitro showed 3C-DFE to have a surprisingly weak binding affinity of 2695 nM at 5-HT2A with negligible affinity at 5-HT2C,[3]: 737 making it only slightly higher affinity than mescaline, despite its higher potency in vivo.
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Preferred IUPAC name
1-[4-(2,2-Difluoroethoxy)-3,5-dimethoxyphenyl]propan-2-amine | |
Other names
3C-DFE
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Identifiers | |
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3D model (JSmol)
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ChemSpider |
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PubChem CID
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Properties | |
C13H19FNO3 | |
Molar mass | 275.292 g/mol |
Melting point | 171–172 °C (340–342 °F; 444–445 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
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