5-I-R91150 (or R93274) is a compound that acts as a potent and selective antagonist of 5-HT2A receptors.[1] Its main application is as its iodine-123 radiolabeled form, in which it can be used in SPECT scanning[2] in human neuroimaging studies, to examine the distribution of the 5-HT2A receptor subtype in the brain, e.g. with respect to sex and age[3] and in adults with Asperger syndrome[4] or Alzheimer's disease.[5]
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Formula | C23H29FIN3O2 |
Molar mass | 525.407 g·mol−1 |
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An alternative 5-HT2A receptor ligand also used in neuroimaging is altanserin.