5-MeO-NBpBrT (5-Methoxy-N-(4-bromobenzyl)tryptamine) is a N-substituted member of the methoxytryptamine family of compounds. Like other such compounds it acts as an antagonist for the 5-HT2A receptor, with a claimed 100x selectivity over the closely related 5-HT2C receptor.[1] While N-benzyl substitution of psychedelic phenethylamines often results in potent 5-HT2A agonists, it had been thought that N-benzyl tryptamines show much lower efficacy and are either very weak partial agonists or antagonists at 5-HT2A,[2][3] though more recent research has shown stronger agonist activity for 3-substituted benzyl derivatives.[4] Extending the benzyl group to a substituted phenethyl can also recover agonist activity in certain cases.[5]
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Formula | C18H19BrN2O |
Molar mass | 359.267 g·mol−1 |
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