6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide

Summary

6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide (CEPC) is a drug which acts as a potent and selective antagonist for the serotonin 5-HT2C receptor. In animal studies it was found to potentiate the conditioned place preference induced by low-dose amphetamine, demonstrating that 5-HT2C-mediated disinhibition of dopamine release can cause interactions with dopaminergic drugs.[1]

6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide
Identifiers
  • 6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide
CAS Number
  • 1384929-25-2 checkY
PubChem CID
  • 57515146
UNII
  • 2BY259EY9C
Chemical and physical data
FormulaC16H16ClN3O2
Molar mass317.77 g·mol−1
3D model (JSmol)
  • Interactive image
  • c3cccnc3NC(=O)N(c1cc2Cl)CCc1cc2OCC

See also edit

References edit

  1. ^ McCorvy JD, Harland AA, Maglathlin R, Nichols DE (November 2011). "A 5-HT(2C) receptor antagonist potentiates a low dose amphetamine-induced conditioned place preference". Neuroscience Letters. 505 (1): 10–3. doi:10.1016/j.neulet.2011.07.036. PMC 3213641. PMID 21827831.