7-Methylguanine is a modified purine nucleobase. It is a methylated version of guanine. The 7-methylguanine nucleoside is called 7-methylguanosine. However, the free 7-methylguanine base is not involved in the synthesis of nucleotides and not incorporated directly into nucleic acids.[1][2] 7-Methylguanine is a natural inhibitor of poly (ADP-ribose) polymerase (PARP) and tRNA guanine transglycosylase (TGT) - and thus may exert anticancer activity.[3][4][5] For example, it was demonstrated that 7-methylguanine could accelerate apoptotic death of BRCA1-deficient breast cancer cells induced by cisplatin and doxorubicin.[6]
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IUPAC name
7-Methylguanine
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Preferred IUPAC name
2-Amino-7-methyl-1,7-dihydro-6H-purin-6-one | |
Other names
N7-Methylguanine; Epiguanine
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Identifiers | |
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3D model (JSmol)
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174245 | |
ChEBI |
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ChemSpider |
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ECHA InfoCard | 100.008.575 |
EC Number |
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PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C6H7N5O | |
Molar mass | 165.156 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
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