Tyrosine-protein kinase ABL2 also known as Abelson-related gene (Arg) is an enzyme that in humans is encoded by the ABL2 gene.[5][6]
ABL2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | ABL2, ABLL, ARG, ABL proto-oncogene 2, non-receptor tyrosine kinase | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 164690 MGI: 87860 HomoloGene: 5278 GeneCards: ABL2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The expression of ABL2 gene is higher in KRAS mutant non-small cell lung cancer.[7] The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length.[6]
ABL2 has been shown to interact with three proteins: Abl gene,[8] catalase,[9] and SORBS2.[10] The protein Abl gene is also known as abelson murine leukemia viral oncogene homolog 1 and is a protein that is encoded by the human ABL1 gene.[11] Catalase is a common enzyme that catalyzes the decomposition of hydrogen peroxide to water and oxygen.[12] SORBS2 is also known as Sorbin and SH3 domain-containing protein 2 and is a protein encoded by the SORBS2 gene in humans.[6][10][13]