ACER3 Knowpia

ACER3
Identifiers
Aliases	ACER3, APHC, PHCA, alkaline ceramidase 3, PLDECO
External IDs	OMIM: 617036 MGI: 1913440 HomoloGene: 5410 GeneCards: ACER3
Gene location (Human)
Chr.	Chromosome 11 (human)
End	77,026,797 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	98,321,208 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; inferior ganglion of vagus nerve; ; corpus callosum; ; pancreatic epithelial cell; ; Brodmann area 46; ; subthalamic nucleus; ; pons; ; medulla oblongata; ; trigeminal ganglion; ; superior vestibular nucleus;
	Top expressed in
	conjunctival fornix; ; cornea; ; interventricular septum; ; hair follicle; ; sciatic nerve; ; skin of back; ; skin of abdomen; ; epithelium of stomach; ; right lung; ; otolith organ;
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; hydrolase activity; phytoceramidase activity; N-acylsphingosine amidohydrolase activity; dihydroceramidase activity; ceramidase activity; calcium ion binding; zinc ion binding; metal ion binding;
Cellular component	integral component of membrane; integral component of Golgi membrane; integral component of endoplasmic reticulum membrane; Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; endoplasmic reticulum; membrane;
Biological process	sphingosine biosynthetic process; sphingolipid biosynthetic process; phytosphingosine biosynthetic process; ceramide metabolic process; positive regulation of cell population proliferation; inflammatory response; myelination; regulation of programmed cell death; ceramide catabolic process; lipid metabolism; sphingolipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	55331
	66190
	ENSG00000078124
	ENSMUSG00000030760
	Q9NUN7
	Q9D099
	NM_001300953; NM_001300954; NM_001300955; NM_018367
	NM_025408
	NP_001287882; NP_001287883; NP_001287884; NP_060837
	NP_079684; NP_001347544; NP_001347545; NP_001347546
	Wikidata
View/Edit Human	View/Edit Mouse

Alkaline ceramidase 3 also known as ACER3 is a ceramidase enzyme which in humans is encoded by the ACER3 gene.^[5]^[6]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000078124 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030760 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mao C, Xu R, Szulc ZM, Bielawska A, Galadari SH, Obeid LM (July 2001). "Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide". J. Biol. Chem. 276 (28): 26577–88. doi:10.1074/jbc.M102818200. PMID 11356846.
^ Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys. Acta. 1781 (9): 424–34. doi:10.1016/j.bbalip.2008.06.002. PMC 2614331. PMID 18619555.

External links edit

Human ACER3 genome location and ACER3 gene details page in the UCSC Genome Browser.

Further reading edit

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Wheeler HE, Metter EJ, Tanaka T, et al. (2009). Gibson G (ed.). "Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging". PLOS Genet. 5 (10): e1000685. doi:10.1371/journal.pgen.1000685. PMC 2752811. PMID 19834535.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000078124 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030760 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11356846-5] Mao C, Xu R, Szulc ZM, Bielawska A, Galadari SH, Obeid LM (July 2001). "Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide". J. Biol. Chem. 276 (28): 26577–88. doi:10.1074/jbc.M102818200. PMID 11356846.

[pmid18619555-6] Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys. Acta. 1781 (9): 424–34. doi:10.1016/j.bbalip.2008.06.002. PMC 2614331. PMID 18619555.

[5]

[6]

[1]

[2]

[3]

[4]

Summary

References edit

External links edit

Further reading edit