ADAM8 Knowpia

ADAM8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DD8
Identifiers
Aliases	ADAM8, CD156, CD156a, MS2, ADAM metallopeptidase domain 8
External IDs	OMIM: 602267 MGI: 107825 HomoloGene: 74384 GeneCards: ADAM8
Gene location (Human)
Chr.	Chromosome 10 (human)
End	133,276,868 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	139,572,475 bp
RNA expression pattern
	Top expressed in
	blood; ; spleen; ; monocyte; ; bone marrow cells; ; pancreatic ductal cell; ; periodontal fiber; ; appendix; ; upper lobe of left lung; ; right lung; ; oocyte;
	Top expressed in
	trachea; ; calvaria; ; vein; ; thymus; ; olfactory epithelium; ; cervix; ; inferior vena cava; ; blood; ; spleen; ; lip;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein self-association; peptidase activity; protein binding; metalloendopeptidase activity; hydrolase activity; cell adhesion molecule binding; calcium ion binding; serine-type endopeptidase activity; metallopeptidase activity; zinc ion binding;
Cellular component	cytoplasm; integral component of membrane; alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex; membrane; tertiary granule; integral component of plasma membrane; cell surface; specific granule; dense core granule membrane; podosome; phagolysosome; alpha9-beta1 integrin-ADAM8 complex; plasma membrane; specific granule membrane; tertiary granule membrane; ficolin-1-rich granule membrane;
Biological process	positive regulation of inflammatory response; extracellular matrix disassembly; proteolysis; positive regulation of cellular extravasation; positive regulation of neutrophil extravasation; positive regulation of protein processing; regulation of cell-cell adhesion; positive regulation of protein secretion; inflammatory response; cellular response to hypoxia; positive regulation of T cell migration; positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; positive regulation of acute inflammatory response; cell morphogenesis; positive regulation of thymocyte apoptotic process; positive regulation of bone resorption; negative regulation of neuron apoptotic process; positive regulation of fibronectin-dependent thymocyte migration; positive regulation of eosinophil migration; positive regulation of NF-kappaB transcription factor activity; leukocyte migration involved in inflammatory response; positive regulation of membrane protein ectodomain proteolysis; positive regulation of protein kinase B signaling; positive regulation of T cell differentiation in thymus; lymphocyte chemotaxis; positive regulation of cell adhesion; angiogenesis; neutrophil degranulation; cell-cell adhesion; positive regulation of MAP kinase activity; positive regulation of innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	101
	11501
	ENSG00000151651
	ENSMUSG00000025473
	P78325
	Q05910
	NM_001109; NM_001164489; NM_001164490
	NM_001291066; NM_007403
	NP_001100; NP_001157961; NP_001157962
	NP_001277995; NP_031429
	Wikidata
View/Edit Human	View/Edit Mouse

A Disintegrin and metalloproteinase domain-containing protein 8 is an enzyme that in humans is encoded by the ADAM8 gene.^[5]^[6]

Function edit

This gene encodes a member of the ADAM (a disintegrin and metalloproteinase domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell–cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration.^[6]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151651 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025473 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yoshiyama K, Higuchi Y, Kataoka M, Matsuura K, Yamamoto S (April 1997). "CD156 (human ADAM8): expression, primary amino acid sequence, and gene location". Genomics. 41 (1): 56–62. doi:10.1006/geno.1997.4607. PMID 9126482.
^ ^a ^b "Entrez Gene: ADAM8 ADAM metallopeptidase domain 8".

External links edit

The MEROPS online database for peptidases and their inhibitors: M12.208
ADAM8 human gene location in the UCSC Genome Browser.
ADAM8 human gene details in the UCSC Genome Browser.
PDBe-KB provides an overview of all the structure information available in the PDB for Human Disintegrin and metalloproteinase domain-containing protein 8 (ADAM8)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.