Aceprometazine (INN) is a phenothiazine derivative prescription drug with neuroleptic and anti-histamine properties It is not widely prescribed, and may be associated with drug-induced Parkinsonism.[1] It may be used in combination with meprobamate for the treatment of sleep disorders. This combination is available in France under the trade name Mepronizine.
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Routes of administration | Oral |
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Metabolism | Hepatic |
Excretion | Renal and fecal |
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ECHA InfoCard | 100.033.315 |
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Formula | C19H22N2OS |
Molar mass | 326.46 g·mol−1 |
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It is structurally related to the phenothiazine derivative veterinary drug acepromazine.
Note: The reason for the rearrangement in the sidechain between the precursor and the product is on account of a methadone-type aziridine.
2-Acetylphenothiazine [6631-94-3] (1) 2-Chloropropyldimethylamine [108-14-5] (2)