Acetryptine (INN) (developmental code name W-2965-A), also known as 5-acetyltryptamine (5-AT),[1] is a drug described as an antihypertensive agent which was never marketed.[2] Structurally, acetryptine is a substituted tryptamine, and is closely related to other substituted tryptamines like serotonin (5-hydroxytryptamine).[2] It was developed in the early 1960s.[2][1] The binding of acetryptine to serotonin receptors does not seem to have been well-investigated, although it was assessed at the 5-HT1A and 5-HT1D receptors and found to bind to them with high affinity.[3] The drug may also act as a monoamine oxidase inhibitor (MAOI); specifically, as an inhibitor of MAO-A.[4][5]
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Other names | W-2965-A; 5-Acetyltryptamine; 5-Acetyl-3-(2-aminoethyl)indole; |
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Formula | C12H14N2O |
Molar mass | 202.257 g·mol−1 |
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