Ọba Ọjájá II was born Prince Adeyeye Enitan of Giesi, one of the four royal families of the House of Oranmiyan.^[3] His paternal grandfather was Prince Joseph Olagbaju Adewole Ogunwusi, whose grandfather was Ọba Ọ̀ráyẹ̀gbà (also known as Ooni Orarigba or Orasigba) Ọjájá I, who was the 44th Ooni of Ife and ruled from 1878 to 1880. Through him, he is a direct descendant of Ooni Agbedegbede, who was a descendant of Ooni Giesi (the progenitor of the Giesi royal house), and thus a descendant of Ọọni Lajodogun. Lajodogun was a son of Ọọni Lajamisan (or Lajemisin), who was a grandson of the legendary founder of the Oyo Empire and Benin Empire, Oranmiyan. Oranmiyan was the son or grandson of the first Ooni of Ife, Oduduwa, and thus Ọba Ọjájá II is a descendant of Odùdùwà, one of the early rulers of Ilé Ifẹ̀.

His birth was said to be predicted years before he was conceived; hence, the name Enitan was given by his mother, while his grandfather named him Adeyeye, which means 'the crown befits the throne'.^[4] He is the fifth child in the family of seven.

He started his elementary education at Subuola Memorial Nursery and Primary School, Ibadan, and Ibadan District Council, Akobo, Ibadan. He then proceeded to Loyola College, Ibadan, and later to St. Peters Secondary School, Ile-Ife, where he received his secondary school certificate (SSCE). He graduated as an accountant from The Polytechnic, Ibadan.^[5]

He is a member of the Institute of Chartered Accountants of Nigeria. He is also an associate accounting technician. Oba Ogunwusi is a certified member of the Institute of Directors. He is also a member of the Global Real Estate Institute. He holds a number of honorary doctorate degrees: one in public administration from the University of Nigeria, Nsukka, and another in law from Igbinedion University.

Oba Ogunwusi is the Chancellor at the University of Nigeria, Nsukka.

Ooni Adeyeye Ogunwusi was selected from the Giesi ruling house of Ile-Ife, among indigenes who were also heirs to the throne, on October 26, 2015. He received his oath of office on December 7, 2015. Some sources describe him as a skilled entrepreneur who has the drive to overcome challenges. Oba Ogunwusi is the spiritual leader of the Yoruba people, now saddled with the responsibility of making supplications to God and the Òrìṣà on behalf of his people and the world at large during annual festivals such as Olojo.^[6]

Shortly after his coronation, Ooni Ogunwusi met with the Alaafin of Oyo and, by so doing, initiated a new era in the history of the Yoruba States. After his coronation, Ooni Ogunwusi met with the Alaafin of Oyo, which marked a significant event in the history of the Yoruba States as it helped to reduce the tension between the two thrones. The Oba is an advocate for the empowerment and emancipation of women and young people. Ile-Ife has experienced notable transformations characterized by initiatives such as beautification, urban redesign, and architectural reconstruction, all directed towards augmenting its attractiveness as a prominent tourist destination under his reign. Oba Ogunwusi is also a renowned philanthropist^[7] who is committed to humanity and an advocate for the less privileged. He has granted support over the years through the House of Oduduwa Foundation and, most recently, through the Hopes Alive Initiative.^[8]

Ogunwusi has been involved in a number of publicized relationships.

He had his first child, Adeola Aanuolouwapo Ogunwusi (born in May 1994), with Omolara Olatubosun in Ibadan when they were both teenagers. They are co-parents. In November 2021, Omolara granted an interview in which she mentioned that he was an absentee father for the first years of their child's life.^[9] They were never married.

In 2008, Ogunwusi married his first wife, Adebukola Bombata, from whom he separated in 2016.^[10]

In March 2016, he married Zaynab Otiti Obanor of the Benin Kingdom and Edo State.^[11] In 2017, Zaynab Otiti filed for divorce from Adeyeye Enitan Ogunwusi. The divorce was finalized in August 2017.

In October 2018, he married Prophetess Morenike Naomi Oluwaseyi.^[12] In December 2021, Morenike Naomi posted on Instagram that they were separated,^[13] but the statement was contradicted hours later by the palace.^{[citation needed]} Naomi continues to play a prominent role in public life.^[14]

Between September and October 2022, he married six wives, including Mariam Anako, an Ebira of Kogi State origin, on September 6, 2022.^[15] Then, Elizabeth Opeoluwa Akinmuda, an Ondo indigene, was betrothed to him on September 7, 2022. Thereafter, he married Tobi Phillips, an Okitipupa, Ondo State native, as his third wife on October 9, 2022. On October 14, 2022, he married Ashley Afolashade Adegoke, an Ile-Ife princess, as his fourth wife. And then, on October 20, 2022, he married yet another Ile-Ife Princess, Ronke Ademiluyi, as his fifth wife. Asake Temitope Morenike Adesegun became the Ooni's sixth wife on October 24, 2022.^[16]

In October 2022, the Nigerian national honor of Commander of the Order of the Federal Republic (CFR) was conferred on him by President Muhammadu Buhari.^[17]

• "Why Oba of Lagos 'snubbing' Ooni of Ife shocked Nigeria". BBC. 27 April 2017.