Adiponectin receptor 1 (AdipoR1) is a protein which in humans is encoded by the ADIPOR1 gene.[5] It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR1.[6]
ADIPOR1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | ADIPOR1, adiponectin receptor 1, ACDCR1, CGI45, PAQR1, TESBP1A, CGI-45 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 607945 MGI: 1919924 HomoloGene: 69199 GeneCards: ADIPOR1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Similar to G protein-coupled receptors (GPCRs), AdipoR1 also possesses 7 transmembrane domains. However, AdipoR1 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins.[5]
The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.[5][7] In 2016, the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoR1 and AdipoR2 identification data, as accused by an anonymous person/group called Ordinary_researchers.[8]