Son of Galeotto IV and Maria Cybo-Malaspina (1609-1652), daughter of Carlo I Cybo-Malaspina, prince of Massa e marquis of Carrara. On 2 September 1637, at the age of 6, he inherited by her grandfather Alexander I's will the dominion of the Duchy of Mirandola,^[1] receiving confirmation of the investiture in 1641 from Emperor Ferdinand III.^[2] Due to his young age, the regency was entrusted to his mother and aunt Maria (1613-1682), who relinquished guardianship in 1648.

In 1666, at the Duchy of Milan, he was in the service of King Charles II of Spain, who knighted him with the Golden Fleece. At the request of Pope Clement IX, he left Mirandola to Venice, from where he set sail the following month for the island of Crete with 9 warships and 3,000 soldiers. After a stopover in Zakynthos, he landed in Candia on 23 August 1669 and joined the French, papal and Venetian forces in the Cretan War against the Ottomans, who had been besieging the Greek city for over twenty years. Alessandro II Pico was appointed field master of the papal troops. However, on 5 September 1669, the defenders of Candia had to sign the surrender to the Turks and were given the honours of war. Alessandro, suffering from malaria, returned to Mirandola where he was triumphantly welcomed.^[1]

He was a prince who loved the arts and had the church of Gesù e the church of the Servants of Mary. He had a library and an art gallery set up, modernised the castle of the Pico family, and paved all the streets of Mirandola. Alessandro Pico protected the arts: from painting (worthy of note is the gallery frescoed by Biagio Falcieri for the rich picture gallery that he set up through costly purchases) to music, calling Giovanni Battista Bassani to court. Finally, Alessandro tried to obtain the investiture of Mirandola as a bishopric, but to no avail.^[2]

On 29 April 1656 he married Anna Beatrice d'Este, daughter of Alfonso III , Duke of Modena and Isabella of Savoy, by whom he had nine children, in addition to two natural children.^[2][3]

Upon his death, he left the reign of the Duchy of Mirandola to his young nephew Francesco Maria II, entrusting its management to his sister Brigida Pico.^[2]

• Bruno Andreolli (2015). "PICO, Alessandro II". PICO, Alessandro II in "Dizionario Biografico". Dizionario biografico degli italiani. Vol. 83.
• Pompeo Litta (1835). Famiglie celebri di Italia. Pico della Mirandola. Torino. [ISBN unspecified].
• Miroslav Marek. "Pico 2".
• Felice Ceretti (1880). Il viaggio di Alessandro II Pico all'isola di Candia. Narrazione di Gianfrancesco Piccinini. Vol. X. pp. 49–92.
• Felice Ceretti (1893). Carteggio del duca Alessandro II Pico con Monsignor Conte Uguccione Rangoni. Vol. XX.
• Felice Ceretti (1897). Trattato seguito nel 1665 fra il duca Carlo Emanuele II di Savoia ed il duca della Mirandola Alessandro II per la coltivazione di miniere. 4. Vol. VIII. pp. 129–131.
• Felice Ceretti (1907). Biografie pichensi. Vol. I. Mirandola. pp. 46–85.{{cite book}}: CS1 maint: location missing publisher (link)
• Memorie di un cuoco di Casa Pico. Banchetti, cerimoniali e ospitalità di una corte al suo tramonto. Mirandola. 2002.{{cite book}}: CS1 maint: location missing publisher (link)
• Cronaca della Mirandola di Giovan Francesco Piccinini (1682-1720). La fine di un ducato nelle memorie del chirurgo di corte. Mirandola. 2010.{{cite book}}: CS1 maint: location missing publisher (link)

• Castle of the Pico
• Church of Gesù, Mirandola
• Cretan War (1645–1669)
• Duchy of Mirandola
• Mirandola Mint