His first strip was Charlie Chan (1938–1942), an adaptation of the popular detective novels for the McNaught Syndicate. For five months in 1943 he drew a minor superhero, Captain Triumph, for Quality Comics' Crack Comics.

For a year he drew the strip Dan Dunn with writer Allen Saunders. Dunn ended on October 3, 1943, and the next day their Kerry Drake debuted. Originally a district attorney's investigator, Drake became a municipal police officer when Sandy Burns, his secretary and fiancee, was murdered by Trinket and Bulldozer. As both a DA's man and a city cop, he battled a series of flamboyant villains, including Bottleneck, Mother Whistler and No-Face. Ghost-written by Saunders from its inception until the early 1970s after Andriola accepted an award for Saunders' writing without giving him credit,^{[1][circular reference]} the strip gradually became a soap opera strip focusing on Drake's home life with his wife Mindy and their quadruplets, as Drake's younger brother Lefty, a private eye, took over more of the adventure plots. Andriola was assisted (and ghosted) by artists Hy Eisman, Fran Matera, Jerry Robinson and Sururi Gumen, the last of whom shared credit with Andriola starting in 1976. Using the pseudonym Alfred James, he collaborated with Mel Casson on the strip It's Me, Dilly from 1957 to 1960. Kerry Drake was canceled after Andriola died in 1983.

He contributed to the book, Ever Since Adam and Eve: A Pictorial Narrative of the Battle of the Sexes in Original Drawings by 86 Famous Cartoonists (McGraw Hill, 1955).

Andriola received the National Cartoonists Society's Silver T-square Award in 1970 and their Reuben Award in 1971.^[2]

• Lambiek Comiclopedia
• Kerry Drake Toonopedia
• Billy Ireland Cartoon Library & Museum Art Database