Alimemazine (INN), also known as trimeprazine, (brand names Nedeltran, Panectyl, Repeltin, Therafene, Theraligene, Theralen, Thegalin, Theralene, Vallergan, Vanectyl, and Temaril), commonly provided as a tartrate salt, is a phenothiazine derivative that is used as an antipruritic (it prevents itching from causes such as eczema or poison ivy, by acting as an antihistamine).^[2] It also acts as a sedative, hypnotic, and antiemetic for prevention of motion sickness. Although it is structurally related to drugs such as chlorpromazine, it is not used as an antipsychotic.^[3] In the Russian Federation, it is marketed under the brand name Teraligen for the treatment of anxiety disorders (including GAD), organic mood disorders, sleep disturbances, personality disorders accompanied by asthenia and depression, somatoform autonomic dysfunction and various neuroses.^[4]

Alimemazine

Clinical data
Other names	trimeprazine (BAN UK), trimeprazine (USAN US)
AHFS/Drugs.com	International Drug Names
Pregnancy category	AU: C
Routes of administration	Oral
ATC code	R06AD01 (WHO)
Legal status
Legal status	UK: POM (Prescription only)
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	4.78 ± 0.59 hours[1]
Identifiers
IUPAC name N,N,2-trimethyl-3-phenothiazin-10-yl-propan-1-amine
CAS Number	84-96-8 Y
PubChem CID	5574
IUPHAR/BPS	7237
DrugBank	DB01246 Y
ChemSpider	5373 Y
UNII	76H78MJJ52
KEGG	D07125 Y
ChEMBL	ChEMBL829 Y
CompTox Dashboard (EPA)	DTXSID9023708
ECHA InfoCard	100.001.434
Chemical and physical data
Formula	C18H22N2S
Molar mass	298.45 g·mol−1
3D model (JSmol)	Interactive image
SMILES S2c1ccccc1N(c3c2cccc3)CC(C)CN(C)C
InChI InChI=1S/C18H22N2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3 Y Key:ZZHLYYDVIOPZBE-UHFFFAOYSA-N Y
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Alimemazine is not approved for use in humans in the United States. The combination of alimemazine and prednisolone (commonly sold under the brand name Temaril-P) is licensed as an antipruritic and antitussive in dogs.