Born in Tel Aviv during the Mandate era, Degani was a member of HaNoar HaOved during his youth, becoming a member of its secretariat in 1942. He studied public administration at the Hebrew University of Jerusalem.^[1]

Having been a co-ordinator for the Moshav Youth, he became a member of the Moshavim Movement's secretariat, and served as director of its Department of Youth Settlement and Security. He also worked as a trainer for immigrants in moshavim in the Negev desert.

He joined Mapai in 1944, and was a director of its youth leadership. He was on the party's list for the 1955 elections, and although he failed to win a seat, he entered the Knesset on 19 December 1957 as a replacement for Aharon Remez.^[2] He retained his seat in elections in 1959 and 1961. In July 1965 he was amongst the Mapai members that left the party to establish Rafi under the leadership of David Ben-Gurion.^[3] Although he lost his seat in the November 1965 elections, he returned to the Knesset on 8 December that year as a replacement for Tzvi Tzur,^[4] who resigned his seat shortly after the elections. He lost his seat again in the 1969 elections.

Degani was also a member of the Histadrut's co-ordinating committee, and was responsible for co-operatives in Hevrat Ovdim between 1970 and 1975.

Between 1975 and 1995 he served as head of Hefer Valley Regional Council.

• Amos Degani on the Knesset website