Andrew Clarke may refer to:

• Andrew Clarke (British Army officer, born 1793) (1793–1847), Governor of Western Australia
• Sir Andrew Clarke (British Army officer, born 1824) (1824–1902), Governor of the Straits Settlements, son of the above
• Andrew Clarke (actor) (born 1954), Australian actor
• Andrew Clarke (British politician) (1868–1940), Labour Member of Parliament 1923–1924, and 1929
• Andrew Clarke (cricketer, born 1961), English former cricketer
• Andrew Clarke (cricketer, born 1975), English cricketer
• Andrew Clarke (Trinidadian cricketer) (born 1945), Trinidadian cricketer
• Andy Clarke (footballer) (born 1967), English former footballer
• Andy Clarke (businessman) (born 1964), British businessman
• Andy Clarke (comics), British comics artist
• Andy C (Andrew Clarke, born 1973), English DJ
• Andrew Clarke, a fictional character from The Breakfast Club
• Andrew Clarke, Australian composer who collaborates with artist Jess Johnson