The hospital was originally named William Angliss Hospital and then changed to Angliss Hospital. It was established in 1939^[3] and named after Sir William Charles Angliss, a respected local politician and philanthropist who contributed financially to the hospital's foundation.^[4] The Angliss family continued to play a significant role in the hospitals growth and management, well into the 20th Century. In 1945 a decision was made to relocate the hospital due to increased demand, and in 1958, Lady Angliss opened the hospital in its now present location. Funding from the Angliss' charitable foundation allowed for the hospital to build an additional 27 beds in 1965.^[4] In 2010 the hospital celebrated the 85,000th birth to have occurred at the hospital.^[4]

The Angliss Hospital is considered a medium metropolitan hospital by the Australian Institute of Health and Welfare, and has an Emergency Department, Radiology, Midwifery, Intensive Care, Obstetric, Paediatric and Rehabilitation departments. In addition to these facilities, the hospital operates the aged care facility located on adjacent Edward Street.^[1] The Intensive Care Unit (ICU) at Angliss Hospital was completed in 2018, at a cost of $20 million, adding 14 intensive care beds to the hospital as well as a new short-stay expansion of the hospital's emergency department.^[5][6]

In 2018, the recently re-elected Andrews government pledged to expand the hospital with an additional 25 hospital beds. The planned expansion is considered an extension of the most recent development at the hospital completed in 2018, which added an intensive care unit to the hospital and a fourth floor. The cost of the expansion is around $170 million and includes an additional 120 beds at a nearby aged care facility.^[7]

• William Angliss