|Father||Michael IX Palaiologos|
|Mother||Rita of Armenia|
She was a daughter of the Byzantine co-emperor Michael IX Palaiologos and his wife, Rita of Armenia. Already in 1304, her hand was sought by the Epirote regent, Anna Palaiologina Kantakouzene, for her son Thomas I Komnenos Doukas; the marriage eventually took place in ca. 1307. When Thomas was murdered by his nephew, Nicholas Orsini, in 1318, the latter took Anna as his wife. She died in 1320.