This scan is conducted between 18 and 22 weeks' gestation, but most often performed at 19 weeks, as a component of routine prenatal care. Prior to 18 weeks' gestation, the fetal organs may be of insufficient size and development to allow for ultrasound evaluation. Scans performed beyond 22 weeks' gestation may limit the ability to seek pregnancy termination, depending on local legislation.^[1]

Two-dimensional (2D) is used to evaluate fetal structures, placenta, and amniotic fluid volume. Maternal pelvic organs are also evaluated. Views are obtained using an abdominal ultrasound probe, but a vaginal ultrasound probe may also be used to evaluate for placenta previa and cervical length. Three-dimensional (3D) ultrasound is not recommended for routine use during anomaly scan, but 3D ultrasound may be used to further evaluate suspected abnormalities in specific fetal features.^[3]

A standard anatomy scan typically includes:^[4]

• Fetal number, including number of amnionic sacs and chorionic sacs for multiple gestations
• Fetal cardiac activity
• Fetal position relative to the uterus and cervix
• Location and appearance of the placenta, including site of umbilical cord insertion
• Amnionic fluid volume
• Gestational age assessment
• Fetal weight estimation
• Fetal anatomical survey
• Evaluation of the maternal uterus, tubes, ovaries, and bladder when appropriate^[4]

Second-trimester ultrasound screening for aneuploidies, such as Edwards syndrome and Patau syndrome, is based on looking for soft markers and some predefined structural abnormalities. Soft markers are variations from normal anatomy, which are more common in aneuploid fetuses compared to euploid ones. These markers are often not clinically significant and do not cause adverse pregnancy outcomes, but used in order to decide whether additional tests, which will be more accurate, are needed.^[5] Placental evaluation is vital for planning method of delivery, as attempting natural childbirth can cause fatal amounts of blood loss in the mother if the placenta is covering the cervix (placenta praevia) and significantly increases the risk of stillbirth. Additionally, placental and umbilical cord abnormalities are also associated with certain fetal genetic abnormalities.^[3]

Sex determination edit

Fetal sex is often noted during the anomaly scan, but can also be detected during the quad scan. However, performing an ultrasound for the sole purpose of determining fetal sex without a medical indication is not recommended.^[1]

Limitations edit

Although ultrasound is a useful screening tool for fetal anomalies, the sensitivity of this scan is highly variable and potentially detects only 40% of all fetal anomalies. The ability of this scan to detect structural fetal abnormalities depends on a variety of factors. These factors include the severity of the anomaly, the background risk of the study population, gestational age at time of scan, the expertise of the ultrasound technician and interpreting obstetrician, and maternal obesity.^[1]

• Nuchal scan