Antonia was born in Florence in 1401 and married at a young age.^[1] She and her husband had one child, a son.^[2]

After her husband's death in 1428, she joined the Third Order of Saint Francis. She then joined a women's community in Foligno, where she was soon appointed superior. In 1433, she was transferred to L'Aquila to supervise a monastery, a position she held for thirteen years. Desiring a more austere life, she then entered the Corpus Christi Monastery of the Poor Clares in L'Aquila, where she became abbess.^[3] Her spiritual director was John of Capistrano.^[4]

Antonia died on 29 February 1472. Many miracles occurred at her tomb and her body has remained incorrupt. She was beatified by Pope Pius IX.^[5] in 1847.