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Azalanstat

Summary

Azalanstat (INN,[1] codenamed RS-21607) is an anti-obesity drug acting as a lanosterol 14α-demethylase inhibitor.[2][3]

Azalanstat
Clinical data
ATC code
  • None
Identifiers
  • 4-({[(2S,4S)-2-[2-(4-Chlorophenyl)ethyl]-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl}sulfanyl)aniline
CAS Number
  • 143393-27-5 ☒N
PubChem CID
  • 60876
ChemSpider
  • 54858 checkY
UNII
  • 2NL79NI1WS
KEGG
  • D03025 checkY
ChEMBL
  • ChEMBL70611 checkY
Chemical and physical data
FormulaC22H24ClN3O2S
Molar mass429.96 g·mol−1
3D model (JSmol)
  • Interactive image
  • Clc1ccc(cc1)CC[C@@]2(OC[C@H](O2)CSc3ccc(N)cc3)Cn4ccnc4
  • InChI=1S/C22H24ClN3O2S/c23-18-3-1-17(2-4-18)9-10-22(15-26-12-11-25-16-26)27-13-20(28-22)14-29-21-7-5-19(24)6-8-21/h1-8,11-12,16,20H,9-10,13-15,24H2/t20-,22-/m0/s1 checkY
  • Key:VYNIUBZKEWJOJP-UNMCSNQZSA-N checkY
 ☒NcheckY (what is this?)

References edit

  1. ^ "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names (Rec. INN): List 36" (PDF). World Health Organization. p. 141. Retrieved 3 January 2017.
  2. ^ Walker KA, Kertesz DJ, Rotstein DM, Swinney DC, Berry PW, So OY, et al. (July 1993). "Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering". Journal of Medicinal Chemistry. 36 (15): 2235–7. doi:10.1021/jm00067a022. PMID 8340925.
  3. ^ Burton PM, Swinney DC, Heller R, Dunlap B, Chiou M, Malonzo E, et al. (August 1995). "Azalanstat (RS-21607), a lanosterol 14 alpha-demethylase inhibitor with cholesterol-lowering activity". Biochemical Pharmacology. 50 (4): 529–44. doi:10.1016/0006-2952(95)00152-p. PMID 7646560.