Sultan Azim ud-Din II (reigned 1763–1764, 1778–1791), was the 21st Sultan of Sulu. He was the son of Sultan Bantilan Muizz ud-Din, and cousin to Sultan Muhammad Israil ud-Din.^[1]

After the death of Sultan Bantilan Muizz ud-Din in 1763, he became the Sultan of Sulu; which lasted until 1764 when the British forced the restoration of the former Sultan Azim ud-Din I.^{[citation needed]}

In 1778, he poisoned his cousin and the reigning Sultan Muhammad Israil ud-Din which led to his proclamation as the new sultan for the second time.^{[citation needed]}