Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), popularly known as baboon syndrome because of its resemblance to the distinctive red buttocks displayed by female baboons, is a systemic dermatitis characterized by well-demarcated patches of erythema distributed symmetrically on the buttocks.[1] The cause of the syndrome may be drug-related: i.e., induced by systemic administration of hydroxyzine,[2] penicillin,[3] iodinated radio contrast media,[4] and others.
Baboon syndrome | |
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Specialty | Dermatology |
The typical rash commonly appears on buttocks. This then resembles the colour of a baboon's buttocks. Other areas like upper inner thigh and armpits, may be affected by the rash. The rashes are red and well-defined. The presentation is typically symmetrical and not associated with systemic symptoms.[5]
Treatment of symmetrical drug related intertriginous and flexural exanthema involves identifying and stopping the causative agent. Topical steroids can help to reduce the redness.[6]
Baboon syndrome affects both sexes equally, and can occur at any age, but seems to be more common in childhood than in adulthood.[7]