Bamipine Knowpia

Bamipine
Clinical data
Trade names	Soventol
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral?, topical
ATC code	D04AA15 (WHO) R06AX01 (WHO);
Identifiers
	IUPAC name N-benzyl-1-methyl-N-phenyl-piperidin-4-amine;
CAS Number	4945-47-5 ;
PubChem CID	72075;
ChemSpider	65061 ;
UNII	Y6BHZ28O92;
KEGG	D07197 ;
ChEMBL	ChEMBL520400 ;
CompTox Dashboard (EPA)	DTXSID5057751 ;
ECHA InfoCard	100.023.261
Chemical and physical data
Formula	C19H24N2
Molar mass	280.415 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES N(c1ccccc1)(Cc2ccccc2)C3CCN(C)CC3;
	InChI InChI=1S/C19H24N2/c1-20-14-12-19(13-15-20)21(18-10-6-3-7-11-18)16-17-8-4-2-5-9-17/h2-11,19H,12-16H2,1H3 ; Key:VZSXTYKGYWISGQ-UHFFFAOYSA-N ;
	(verify)

Bamipine (trade name Soventol)^[1] is a pharmaceutical drug acting as an H₁ antihistamine with anticholinergic properties.^[2] It is used as an antipruritic ointment.^[3] No oral use is known.^[4]

Adverse effects edit

Side effects are typical of an old (first-generation) antihistamine: tiredness in adults, agitation in children, mydriasis (dilation of the pupils). These effects are rare when bamipine is applied topically as an ointment. Allergic and hypersensitivity reactions are also rare. Acute eczema can be worsened by bamipine ointment.^[5]

Contraindications and interactions edit

No clinically relevant contraindications or interactions with other drugs are known.^[5]

Pharmacology edit

Pharmacokinetics edit

When applied topically, the maximal effect is reached after 20 to 60 minutes and lasts up to 48 hours. Bamipine is not absorbed through intact skin in relevant doses.^[5]

References edit

^ Publishing, William Andrew (2013-10-22). Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. p. 523. ISBN 978-0-8155-1856-3.
^ Vardanyan RS (2017). "Chapter 5: 4-Substituted and 1,4-Disubstituted Piperidines". Piperidine-based drug discovery. Amsterdam, Netherlands. p. 191. ISBN 978-0-12-813428-3.{{cite book}}: CS1 maint: location missing publisher (link)
^ WO 0236163, Pairet M, Pieper MP, Meade CJ, Schmelzer C, "Pharmaceutical compositions containing tiotropium salts and antihistamines and their use", published 10 May 2002, assigned to Boehringer Ingelheim
^ International Drug Names: Bamipine.
^ ^a ^b ^c Haberfeld H, ed. (2015). Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag. Soventol-Gel.

[1] Publishing, William Andrew (2013-10-22). Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. p. 523. ISBN 978-0-8155-1856-3.

[2] Vardanyan RS (2017). "Chapter 5: 4-Substituted and 1,4-Disubstituted Piperidines". Piperidine-based drug discovery. Amsterdam, Netherlands. p. 191. ISBN 978-0-12-813428-3.{{cite book}}: CS1 maint: location missing publisher (link)

[3] WO 0236163, Pairet M, Pieper MP, Meade CJ, Schmelzer C, "Pharmaceutical compositions containing tiotropium salts and antihistamines and their use", published 10 May 2002, assigned to Boehringer Ingelheim

[4] International Drug Names: Bamipine.

[AC-5] Haberfeld H, ed. (2015). Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag. Soventol-Gel.

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Summary

Adverse effects edit

Contraindications and interactions edit

Pharmacology edit

Pharmacokinetics edit

References edit