Barsa-Kelmes Nature Reserve (Kazakh: Барсакелмес мемлекеттік табиғи қорығы, Barsakelmes memlekettık tabiği qoryğy) is a wildlife refuge on the former island of Barsa-Kelmes in Kyzylorda Region of Kazakhstan, in Central Asia.

Barsa-Kelmes Nature Reserve
IUCN category Ia (strict nature reserve)
Location	Kyzylorda Region, Kazakhstan
Coordinates	45°38′07″N 59°54′30″E / 45.63528°N 59.90833°E / 45.63528; 59.90833
Area	160 826 ha
Established	1939
UNESCO World Heritage Site
Official name	Cold Winter Deserts of Turan
Type	Natural
Criteria	ix, x
Designated	2023 (45th session)
Reference no.	1693[1]

It was founded in 1939.^[2] The island on which the reserve is situated is in the Aral Sea. Its territory is around 300 square kilometres. Some 250 species of plants constitute its flora. Its fauna numbers 56 species of animals, and includes, among others, the Transcaspian wild ass, goitered gazelle, corsac fox, and Eurasian wolf. There are 203 bird species in the area.