He was born in the city of Santiago on February 13, 1811. His parents were Carlos de Rojas Valerio and María Antonia Ramos Nazario. His family left the country following the Haitian invasion of 1822. As a teenager he moved to England, where he was educated and adopted English and American constitutionalist doctrines, in addition to acquiring administrative experience as a British government official. Upon returning to the country in 1846, he stood out as one of the most enlightened Cibaeño intellectuals and focused his attention on the technical and administrative reform of the State.

He returned to the Dominican Republic when Independence had already been proclaimed in 1844. He was one of the main drafters of the Manifesto of the Revolution of 1857 waged by the liberals of Cibaeño against Buenaventura Báez, whose victory determined the transfer of the capital of the Republic from Santo Domingo to Santiago. He held positions in the Senate. In 1858 he presided over the Constituent Congress that met in the city of Moca and elected José Desiderio Valverde. In this government he held the position of Vice President. In addition to his political life, he was a lawyer, a profession that he practiced successfully. In 1861 he was one of the first to support the Restoration, becoming one of its leaders. He was chief of operations for President Gaspar Polanco.

It was a short-lived government. He had the initiative to create schools in each town and in the provincial capitals. He contributed to promoting education, while he held important positions, he founded primary and secondary schools. He had other projects to improve communication routes, but he could not carry them out. He ruled from January 24, 1865 to March 24, 1865.

After being removed from office by President Antonio Salcedo and he retired to live in Moca. He held the vice presidency of the Republic three times. He died in Santo Domingo , on October 30, 1865 .