Big Brown may refer to:

• Big Brown (horse), an American thoroughbred racehorse
• Big brown bat, a North American bat
• Big Brown, a nickname for the delivery company United Parcel Service
• Big Brown Box, an Australian online retailer
• Big Brown (poet) (1920–1980), American street performer
• Big Brown, a nickname of retired UFC fighter Brendan Schaub
• Big Brown Power Plant, a former power plant in Texas