Biomanufacturing Knowpia

Biomanufacturing is a type of manufacturing or biotechnology that utilizes biological systems to produce commercially important biomaterials and biomolecules for use in medicines, food and beverage processing, and industrial applications. Biomanufacturing products are recovered from natural sources, such as blood, or from cultures of microbes, animal cells, or plant cells grown in specialized equipment. The cells used during the production may have been naturally occurring or derived using genetic engineering techniques.^{[citation needed]}

Products edit

There are thousands of biomanufacturing products on the market today. Some examples of general classes are listed below:

Medicine edit

Food and beverage edit

Amino acids
Enzymes
Protein supplements

Industrial applications that employ cells and/or enzymes edit

Unit operations edit

A partial listing of unit operations utilized during biomanufacturing includes the following:

Blood plasma fractionation
Cell culture
Cell separation, such as filtration and centrifugation
Fermentation
Homogenization
Column chromatography
Ultrafiltration and/or diafiltration
Clarification, such as filtration
Formulation
Filling vials or syringes for injectable medicines

Equipment and facilities edit

Equipment and facility requirements are dictated by the product(s) being manufactured. Process equipment is typically constructed of stainless steel or plastic. Stainless steel equipment can be cleaned and reused. Some plastic equipment is disposed of after a single use.

Stainless Steel Bioreactors

Products manufactured for medical or food use must be produced in facilities designed and operated according to Good Manufacturing Practice (GMP) regulations. Cleanrooms are often required to control the levels of particulates and microorganisms. Sterilization and aseptic processing equipment are required for production of injectable products.

Employment edit

Skilled professionals are required for positions throughout the life cycle of a biomanufacturing product, which includes:

Details for some of these positions are listed in “The Model Employee,” published by the North Carolina Biotechnology Center.^[1] In addition, the North Carolina Association for Biomedical Research (NCABR) maintains the website About Bioscience that offers free online videos on various careers.^[2]

Education and training edit

Several academic institutions have developed curricula and built facilities to provide education and training in biomanufacturing to students from community colleges, universities, and/or industry. NCBioImpact, established in 2004, is an example of a comprehensive state-wide training network. Member institutions Golden LEAF Biomanufacturing Training and Education Center (BTEC) at North Carolina State University, (BRITE) at North Carolina Central University, and North Carolina Community College System’s BioNetwork operate multidisciplinary centers dedicated to workforce development for the biomanufacturing industry.

MiraCosta College and Solano College in California developed the first bachelor of science degree in biomanufacturing. The degree is largely lab-based and is built on a contextualized science and statistics backbone. The upper division classes recognize the unique environment of biological production where the process sciences and technology thrive in partnership with quality and regulatory compliance.