Boojie Baker (Dan Conway) is a ruthless, greedy talent manager who "discovers" and then exploits unknown rock bands. The film opens in a nightclub with one of Boojie Baker's protégé acts, a band named Charlie, who have clearly been put through the grind already. They begin griping about the royalties they've been fleeced out of, then walk out on him.

Undaunted, Boojie and his loyal but dim-witted assistant Gordy (Ray Sager) walk into a local bar for some cheap drinks and they discover a new band performing, played by real-life Chicago garage rock band The Faded Blue. Promising them a recording contract and ensuing fame, Boojie renames the five-man group "The Big Blast", outfits them in designer suits and sets about to prime them for stardom. This is done by utilizing a bevy of attractive and loose women to seduce a recording engineer, photographing him in the heat of the moment, then blackmailing him into letting The Big Blast cut a single. The group cuts their big hit, and Boojie presumably uses similar tactics to promote the record and garner airplay. However, as the band's popularity grows, it doesn't take long before they begin to wonder why they aren't receiving any money for their labors.

A little later, the Big Blast confronts Boojie in his office and accuse him of swindling them out of their hard-earned money for their record sales and demand that he pay them up front for their work from now on. Being a hard line negotiator, Boojie refuses to budge in that respect, and welcomes the boys to seek fame and fortune in other avenues. To show there are no hard feelings, he even invites them to a party at his apartment. It turns out that this party, replete with liquor, women, and marijuana is a setup, and a "police detective" shows up to raid it. Coincidentally, this is before Boojie arrives, and when he does, it seems that he also has some pull in the "police department". As it happens, he is able to bail the boys out of this serious legal jam; if they agree to sign new contracts which expands Boojie's hold on them to five years, and Boojie would now be receiving over 80% of their profits. One by one, each of the five members concedes to Boojie's demands. After they leave, the "detective" hits up Boojie for some of the grass.

Back in the studio, the group begins to unravel, internal bickering starts to swell, and they just can't seem to cut their follow-up hit. In the climax, the group decides instead to bring down Boojie at the expense of their own fame and fortune by sabotaging a television appearance Boojie has lined up by showing up drunk and singing a thinly-disguised musical flipping-of-the-bird to him. Having humiliated Boojie, the group then rips up Boojie's contract to them. Angry and defeated, Boojie and Gordy storm out of the studio, presumably to go look for another rock and roll band to manage and manipulate thus starting the cycle all over again. "Oh well, that's show business", one band member says.

The film ends with a zany MOS montage of the band running around various Chicago and Cleveland landmarks, which was inspired by the comic stylings of Richard Lester's films of the Beatles.^{[citation needed]} Live footage is from different clubs, one was the now famous Agora Alpha in Little Italy Cleveland!

Most notable in Blast-Off Girls is a cameo appearance from real-life KFC founder Colonel Harland Sanders. Lewis was able to enlist Sanders for the film through his connections in his advertising firm. The scene was shot in a single day at the local Kentucky Fried Chicken restaurant in Cleveland, Ohio. Lewis recalled Sanders as being very difficult to work with because Sanders made a number of self-serving demands which included requesting multiple rehearsals, top-billing for the film, and wanting to direct the scene himself.^[1]

Allmovie wrote of the film, "Fans of Lewis' trashy canon won't find much excitement here, as the trim running time moves at a snail's pace and offers few thrills, and those who seek a nostalgic dose of garage rock are likely to be put off by the shrill musical soundtrack. All other viewers will be amazed by the rock-bottom production values, as this is one of the cheapest looking films of Lewis' low-budget career."^[2]

• Daniel Krogh; John McCarthy. Herschell Gordon Lewis and His World of Exploitation Art.

• Blast-Off Girls at IMDb