A teenager is admitted to the hospital after spitting up blood. Taub also discovers that the boy has been depressed and appears to have been cutting himself. More concern arises when the team breaks into the boy's house and finds his school yearbook with his classmates' faces crossed out and threatening words written about the school, and when Taub checks the contents of the boy's flash drive, he finds disturbing videos of him blowing up homemade pipe bombs and appearing to show misanthropic and sociopathic tendencies.

It is discovered that a piece of one of the bombs ended up lodged in his system, and the foreign material is what has caused his various medical maladies. Taub, however, is torn between sending the videos to the authorities throughout the case, but in the end, decides to mail the flash drive to the police.

Meanwhile, Cuddy finds blood in her urine and undergoes tests for possible kidney cancer, while House grapples with emotionally supporting her, avoiding her, and denying that she is actually sick. Cuddy goes through several dreams that show first herself, House and the team in a parody of Two and a Half Men, then in a Zombie scenario where House kills his zombie colleagues, next a Western version similar to Butch Cassidy and the Sundance Kid, a 1950s sitcom and finally, a musical number where House who's wearing an outfit that's a combination of a ringmaster and a cabaret magician along with eyeliner sings the song Get Happy accompanied by various dancers with Cuddy joining in. The number then abruptly ends with Cuddy awakening and learning that while she was hospitalized before her kidney problems were found to be a benign tumor.

After speaking with her sister, Cuddy realizes that when House came to see her during her illness, he was under the influence of Vicodin. Realizing that he is unable to open up completely and share the pain that she considers to be part of any meaningful relationship, she ends their relationship.

The episode is concluded with a scene that echoes the last scene of the previous season's finale ("Help Me"): House is sitting on his bathroom floor with a bottle of Vicodin in his hand. He expectantly looks at the doorway. Resigned, and with no Cuddy to save him, he takes the pills.

Zack Handlen of The A.V. Club gave this episode a B+ rating, praising "Bombshells" despite the campy dream sequences.^[1]

• "Bombshells" at Fox.com
• "Bombshells" at IMDb