Bradykinin receptor B1 (B1) is a G-protein coupled receptor encoded by the BDKRB1 gene in humans. Its principal ligand is bradykinin, a 9 amino acid peptide generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The B1 receptor is one of two of G protein-coupled receptors that have been found which bind bradykinin and mediate responses to these pathophysiologic conditions.
BDKRB1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | BDKRB1, B1BKR, B1R, BDKRB2, BKB1R, BKR1, BRADYB1, Bradykinin receptor B1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 600337 MGI: 88144 HomoloGene: 570 GeneCards: BDKRB1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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B1 protein is synthesized de novo following tissue injury and receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses.[5]
Classical agonist of this receptor includes bradykinin1-8 (bradykinin with the first 8 amino acid) and antagonist includes [Leu8]-bradykinin1-8.[6]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.