Brown Brothers may refer to:

• Brown Bros. & Co. a bank, later merging to become Brown Brothers Harriman & Co.
• Brown Brothers Harriman & Co., the oldest and largest private bank in the United States
• Brown Brothers (engineering) a Scottish engineering company incorporated into Vickers plc
• Brown Brothers Milawa Vineyard, an Australian wine company
• Brown Brothers Tobacco Company, a 19th-century Detroit cigar manufacturing business
• Brown Brothers of Great Eastern Street, London, UK, manufacturer of the Brown quadricycle first sold in 1899
• Six Brown Brothers, a jazz sextet