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CBiPES

Summary

CBiPES is a drug used in scientific research that acts as a selective positive allosteric modulator for the metabotropic glutamate receptor group II subtype mGluR2. It has potentially antipsychotic effects in animal models, and is used for researching the role of mGluR2 receptors in schizophrenia and related disorders.[1][2][3]

CBiPES
Clinical data
ATC code
  • none
Identifiers
  • N-(4'-cyano-[1,1'-biphenyl]-3-yl-N-(3-pyridinylmethyl)ethanesulfonamide
CAS Number
  • 353235-01-5 checkY
PubChem CID
  • 9864510
IUPHAR/BPS
  • 3372
ChemSpider
  • 8040202
UNII
  • TQ25KB5NW9
CompTox Dashboard (EPA)
  • DTXSID70432071 Edit this at Wikidata
Chemical and physical data
FormulaC21H19N3O2S
Molar mass377.46 g·mol−1
3D model (JSmol)
  • Interactive image
  • N#Cc1ccc(cc1)-c(ccc2)cc2N(S(=O)(=O)CC)Cc3cccnc3
  • InChI=1S/C21H19N3O2S/c1-2-27(25,26)24(16-18-5-4-12-23-15-18)21-7-3-6-20(13-21)19-10-8-17(14-22)9-11-19/h3-13,15H,2,16H2,1H3
  • Key:HDVYXILCBYGKGU-UHFFFAOYSA-N

References edit

  1. ^ Johnson MP, Barda D, Britton TC, Emkey R, Hornback WJ, Jagdmann GE, et al. (April 2005). "Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s)". Psychopharmacology. 179 (1): 271–83. doi:10.1007/s00213-004-2099-9. PMID 15717213. S2CID 2699540.
  2. ^ Fell MJ, Katner JS, Johnson BG, Khilevich A, Schkeryantz JM, Perry KW, Svensson KA (March 2010). "Activation of metabotropic glutamate (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute ketamine challenge". Neuropharmacology. 58 (3): 632–9. doi:10.1016/j.neuropharm.2009.11.014. PMID 19951716. S2CID 7262560.
  3. ^ Sanger H, Hanna L, Colvin EM, Grubisha O, Ursu D, Heinz BA, et al. (March 2013). "Pharmacological profiling of native group II metabotropic glutamate receptors in primary cortical neuronal cultures using a FLIPR". Neuropharmacology. 66: 264–73. doi:10.1016/j.neuropharm.2012.05.023. PMID 22659090. S2CID 42448364.