CCR8_(gene) Knowpia

CCR8
Identifiers
Aliases	CCR8, CC-CKR-8, CCR-8, CDw198, CKRL1, CMKBR8, CMKBRL2, CY6, GPRCY6, TER1, C-C motif chemokine receptor 8
External IDs	OMIM: 601834 MGI: 1201402 HomoloGene: 21080 GeneCards: CCR8
Gene location (Human)
Chr.	Chromosome 3 (human)
End	39,333,680 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	119,923,972 bp
RNA expression pattern
	Top expressed in
	appendix; ; gallbladder; ; lymph node; ; blood; ; rectum; ; thymus; ; urinary bladder; ; spleen; ; lower respiratory tract; ; endometrium;
	Top expressed in
	morula; ; pharynx; ; thymus; ; meninges; ; lip; ; spleen; ; stomach; ; amygdala; ; thorax; ; limb;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	C-C chemokine receptor activity; G protein-coupled receptor activity; chemokine receptor activity; coreceptor activity; signal transducer activity; chemokine binding; C-C chemokine binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; intracellular anatomical structure; external side of plasma membrane;
Biological process	positive regulation of cytosolic calcium ion concentration; chemotaxis; chemokine-mediated signaling pathway; G protein-coupled receptor signaling pathway; cell adhesion; immune response; signal transduction; calcium-mediated signaling; cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	1237
	12776
	ENSG00000179934
	ENSMUSG00000042262
	P51685
	P56484
	NM_005201
	NM_007720
	NP_005192
	NP_031746
	Wikidata
View/Edit Human	View/Edit Mouse

Chemokine (C-C motif) receptor 8, also known as CCR8, is a protein which in humans is encoded by the CCR8 gene.^[5] CCR8 has also recently been designated CDw198 (cluster of differentiation w198).

Function edit

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. The ligand of the CCR8 is CCL1.^[6] CCL8 also functions as a CCR8 agonist.^[7]

Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region.^[5]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179934 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042262 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CCR8 chemokine (C-C motif) receptor 8".
^ Garlisi CG, Xiao H, Tian F, Hedrick JA, Billah MM, Egan RW, Umland SP (October 1999). "The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8". Eur. J. Immunol. 29 (10): 3210–5. doi:10.1002/(SICI)1521-4141(199910)29:10<3210::AID-IMMU3210>3.0.CO;2-W. PMID 10540332.
^ Islam SA, Chang DS, Colvin RA, Byrne MH, McCully ML, Moser B, Lira SA, Charo IF, Luster AD (2011). "Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells". Nat. Immunol. 12 (2): 167–77. doi:10.1038/ni.1984. PMC 3863381. PMID 21217759.

External links edit

Human CCR8 genome location and CCR8 gene details page in the UCSC Genome Browser.
"Chemokine Receptors: CCR8". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2008-06-07. Retrieved 2008-12-03.

Further reading edit

Ruibal-Ares BH, Belmonte L, Baré PC, Parodi CM, Massud I, de Bracco MM (2004). "HIV-1 infection and chemokine receptor modulation". Curr. HIV Res. 2 (1): 39–50. doi:10.2174/1570162043484997. PMID 15053339.
Napolitano M, Zingoni A, Bernardini G, Spinetti G, Nista A, Storlazzi CT, Rocchi M, Santoni A (1996). "Molecular cloning of TER1, a chemokine receptor-like gene expressed by lymphoid tissues". J. Immunol. 157 (7): 2759–63. doi:10.4049/jimmunol.157.7.2759. PMID 8816377.
Zaballos A, Varona R, Gutiérrez J, Lind P, Márquez G (1996). "Molecular cloning and RNA expression of two new human chemokine receptor-like genes". Biochem. Biophys. Res. Commun. 227 (3): 846–53. doi:10.1006/bbrc.1996.1595. PMID 8886020.
Samson M, Stordeur P, Labbé O, Soularue P, Vassart G, Parmentier M (1996). "Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor". Eur. J. Immunol. 26 (12): 3021–8. doi:10.1002/eji.1830261230. PMID 8977299. S2CID 41090013.
Tiffany HL, Lautens LL, Gao JL, Pease J, Locati M, Combadiere C, Modi W, Bonner TI, Murphy PM (1997). "Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309". J. Exp. Med. 186 (1): 165–70. doi:10.1084/jem.186.1.165. PMC 2198957. PMID 9207005.
Roos RS, Loetscher M, Legler DF, Clark-Lewis I, Baggiolini M, Moser B (1997). "Identification of CCR8, the receptor for the human CC chemokine I-309". J. Biol. Chem. 272 (28): 17251–4. doi:10.1074/jbc.272.28.17251. PMID 9211859.
Horuk R, Hesselgesser J, Zhou Y, Faulds D, Halks-Miller M, Harvey S, Taub D, Samson M, Parmentier M, Rucker J, Doranz BJ, Doms RW (1998). "The CC chemokine I-309 inhibits CCR8-dependent infection by diverse HIV-1 strains". J. Biol. Chem. 273 (1): 386–91. doi:10.1074/jbc.273.1.386. PMID 9417093.
Goya I, Gutiérrez J, Varona R, Kremer L, Zaballos A, Márquez G (1998). "Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3". J. Immunol. 160 (4): 1975–81. doi:10.4049/jimmunol.160.4.1975. PMID 9469461.
Jinno A, Shimizu N, Soda Y, Haraguchi Y, Kitamura T, Hoshino H (1998). "Identification of the chemokine receptor TER1/CCR8 expressed in brain-derived cells and T cells as a new coreceptor for HIV-1 infection". Biochem. Biophys. Res. Commun. 243 (2): 497–502. doi:10.1006/bbrc.1998.8130. PMID 9480837.
Bernardini G, Hedrick J, Sozzani S, Luini W, Spinetti G, Weiss M, Menon S, Zlotnik A, Mantovani A, Santoni A, Napolitano M (1998). "Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor". Eur. J. Immunol. 28 (2): 582–8. doi:10.1002/(SICI)1521-4141(199802)28:02<582::AID-IMMU582>3.0.CO;2-A. PMID 9521068.
Zingoni A, Soto H, Hedrick JA, Stoppacciaro A, Storlazzi CT, Sinigaglia F, D'Ambrosio D, O'Garra A, Robinson D, Rocchi M, Santoni A, Zlotnik A, Napolitano M (1998). "The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells". J. Immunol. 161 (2): 547–51. doi:10.4049/jimmunol.161.2.547. PMID 9670926.
Efremov R, Truong MJ, Darcissac EC, Zeng J, Grau O, Vergoten G, Debard C, Capron A, Bahr GM (1999). "Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors implications for HIV-1 coreceptor function". Eur. J. Biochem. 263 (3): 746–56. doi:10.1046/j.1432-1327.1999.00553.x. PMID 10469138.
Garlisi CG, Xiao H, Tian F, Hedrick JA, Billah MM, Egan RW, Umland SP (1999). "The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8". Eur. J. Immunol. 29 (10): 3210–5. doi:10.1002/(SICI)1521-4141(199910)29:10<3210::AID-IMMU3210>3.0.CO;2-W. PMID 10540332.
Lee S, Tiffany HL, King L, Murphy PM, Golding H, Zaitseva MB (2000). "CCR8 on human thymocytes functions as a human immunodeficiency virus type 1 coreceptor". J. Virol. 74 (15): 6946–52. doi:10.1128/JVI.74.15.6946-6952.2000. PMC 112211. PMID 10888633.
Howard OM, Dong HF, Shirakawa AK, Oppenheim JJ (2000). "LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8". Blood. 96 (3): 840–5. doi:10.1182/blood.V96.3.840. PMID 10910894.
Rosu-Myles M, Khandaker M, Wu DM, Keeney M, Foley SR, Howson-Jan K, Yee IC, Fellows F, Kelvin D, Bhatia M (2000). "Characterization of chemokine receptors expressed in primitive blood cells during human hematopoietic ontogeny". Stem Cells. 18 (5): 374–81. doi:10.1634/stemcells.18-5-374. PMID 11007922. S2CID 24126030.
Utaipat U, Duerr A, Rudolph DL, Yang C, Butera ST, Lupo D, Pisell T, Tangmunkongvorakul A, Kamtorn N, Nantachit N, Nagachinta T, Suriyanon V, Robison V, Nelson KE, Sittisombut N, Lal RB (2002). "Coreceptor utilization of HIV type 1 subtype E viral isolates from Thai men with HIV type 1-infected and uninfected wives". AIDS Res. Hum. Retroviruses. 18 (1): 1–11. doi:10.1089/088922202753394664. PMID 11804551.
Annunziato F, Cosmi L, Liotta F, Lazzeri E, Manetti R, Vanini V, Romagnani P, Maggi E, Romagnani S (2002). "Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes". J. Exp. Med. 196 (3): 379–87. doi:10.1084/jem.20020110. PMC 2193942. PMID 12163566.
Spinetti G, Bernardini G, Camarda G, Mangoni A, Santoni A, Capogrossi MC, Napolitano M (2003). "The chemokine receptor CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway". J. Leukoc. Biol. 73 (1): 201–7. doi:10.1189/jlb.0302105. PMID 12525579. S2CID 25301611.