CFLAR Knowpia

CFLAR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3H11, 3H13, 2N5R
Identifiers
Aliases	CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASP8 and FADD like apoptosis regulator, cFLIP
External IDs	OMIM: 603599 MGI: 1336166 HomoloGene: 7652 GeneCards: CFLAR
Gene location (Human)
Chr.	Chromosome 2 (human)
End	201,176,687 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	58,798,043 bp
RNA expression pattern
	Top expressed in
	right lung; ; upper lobe of left lung; ; left ventricle; ; blood; ; gastrocnemius muscle; ; bone marrow cells; ; monocyte; ; renal medulla; ; spleen; ; lymph node;
	Top expressed in
	ascending aorta; ; aortic valve; ; proximal tubule; ; right lung; ; right lung lobe; ; ciliary body; ; thymus; ; lateral recess; ; retinal pigment epithelium; ; left lung;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	cysteine-type peptidase activity; protein binding; cysteine-type endopeptidase activity involved in execution phase of apoptosis; enzyme activator activity; cysteine-type endopeptidase activity; peptidase activator activity; protein heterodimerization activity; protease binding; death receptor binding; protein-containing complex binding; cysteine-type endopeptidase activity involved in apoptotic process;
Cellular component	cytosol; CD95 death-inducing signaling complex; ripoptosome; death-inducing signaling complex; membrane raft; cytoplasm;
Biological process	regulation of apoptotic process; execution phase of apoptosis; negative regulation of apoptotic process; proteolysis; positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of necroptotic process; regulation of extrinsic apoptotic signaling pathway via death domain receptors; viral process; apoptotic process; positive regulation of catalytic activity; response to hypoxia; negative regulation of cardiac muscle cell apoptotic process; positive regulation of neuron projection development; cellular response to insulin stimulus; response to testosterone; positive regulation of ERK1 and ERK2 cascade; cellular response to epidermal growth factor stimulus; cellular response to estradiol stimulus; cellular response to hypoxia; cellular response to dexamethasone stimulus; cellular response to nitric oxide; positive regulation of glomerular mesangial cell proliferation; positive regulation of extracellular matrix organization; negative regulation of reactive oxygen species biosynthetic process; negative regulation of cellular response to transforming growth factor beta stimulus; negative regulation of hepatocyte apoptotic process; negative regulation of epithelial cell apoptotic process; positive regulation of hepatocyte proliferation; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; skeletal muscle tissue development; positive regulation of peptidase activity; skeletal muscle atrophy; regulation of skeletal muscle satellite cell proliferation; skeletal myofibril assembly; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; skeletal muscle tissue regeneration; positive regulation of NF-kappaB transcription factor activity; negative regulation of necroptotic process; negative regulation of myoblast fusion; negative regulation of extrinsic apoptotic signaling pathway; response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
	8837
	12633
	ENSG00000003402
	ENSMUSG00000026031
	O15519
	O35732
NM_001127183; NM_001127184; NM_001202515; NM_001202516; NM_001202517;
	NM_001202518; NM_001202519; NM_001308042; NM_001308043; NM_003879; NM_001351590; NM_001351591; NM_001351592; NM_001351593; NM_001351594
NM_001289704; NM_001293804; NM_001293805; NM_009805; NM_207653;
	NM_001355056
NP_001120655; NP_001120656; NP_001189444; NP_001189445; NP_001189446;
	NP_001189447; NP_001189448; NP_001294971; NP_001294972; NP_003870; NP_001338519; NP_001338520; NP_001338521; NP_001338522; NP_001338523
NP_001276633; NP_001280733; NP_001280734; NP_033935; NP_997536;
	NP_001341985
	Wikidata
View/Edit Human	View/Edit Mouse

CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene.^[5]^[6] Also called c-FLIP (FLICE-like inhibitory protein).

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000003402 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026031 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shu HB, Halpin DR, Goeddel DV (Jul 1997). "Casper is a FADD- and caspase-related inducer of apoptosis". Immunity. 6 (6): 751–63. doi:10.1016/S1074-7613(00)80450-1. PMID 9208847.
^ Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE, Tschopp J (Jul 1997). "Inhibition of death receptor signals by cellular FLIP" (PDF). Nature. 388 (6638): 190–5. doi:10.1038/40657. PMID 9217161. S2CID 4341495.

External links edit

Human CFLAR genome location and CFLAR gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: O15519 (CASP8 and FADD-like apoptosis regulator) at the PDBe-KB.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000003402 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026031 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9208847-5] Shu HB, Halpin DR, Goeddel DV (Jul 1997). "Casper is a FADD- and caspase-related inducer of apoptosis". Immunity. 6 (6): 751–63. doi:10.1016/S1074-7613(00)80450-1. PMID 9208847.

[pmid9217161-6] Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE, Tschopp J (Jul 1997). "Inhibition of death receptor signals by cellular FLIP" (PDF). Nature. 388 (6638): 190–5. doi:10.1038/40657. PMID 9217161. S2CID 4341495.

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Summary

References edit

Further reading edit

External links edit